Drosophila Hemocyte Metabolism Genes from mTOR Pathway Study

Transcriptome data indicated a metabolic shift in Drosophila melanogaster larval blood cells following parasitoid wasp infection or genetic mTOR pathway manipulation. The dataset contains genes related to aerobic glycolysis, the oxidative pentose phosphate pathway, and glutaminolysis. It was generated by Ines Anderl through transcriptomic analyses to investigate mTOR's role in hematopoiesis and immunity.

Use Cases

• Identify genes involved in aerobic glycolysis for energy production from the transcriptome data.
• Analyze expression patterns of genes in the oxidative pentose phosphate pathway for NADPH recycling and ROS production.
• Examine glutaminolysis-related genes for their role in glutathione production during hemocyte activation.
• Compare gene expression patterns between wasp-infected and mTor-overexpressing hemocytes from the transcriptomic profiling.

Strengths

• Data is derived from transcriptomic analyses of Drosophila larval hemocytes, a specific and relevant biological model.
• Focuses on evolutionarily conserved mTOR pathway and its connection to metabolism, immunity, and cell fate.
• Includes genes linked to specific metabolic processes: aerobic glycolysis, oxidative pentose phosphate pathway, and glutaminolysis.
• Dataset is openly shared under a CC BY 4.0 license, facilitating reuse.

Limitations

• The dataset is very small at 38.3 KB, indicating limited scope and likely a focused gene list rather than a full transcriptome.
• No row or column counts are provided, making the scale and structure of the tabular data unclear.
• Sample data and specific column names are unavailable, hindering immediate understanding of the data format.

Provenance

Source

Figshare, authored by Ines Anderl.

Collection Method

Generated via transcriptomic analyses of peripheral larval blood cells (hemocytes) from Drosophila melanogaster.

Freshness

Last updated in March 2026.