Cryptococcus Neoformans CO2 Tolerance Genetic and Metabolomic Data

301 deletion mutants of Cryptococcus neoformans showed altered fitness in a competitive growth assay under high CO2 conditions. Laura C. Ristow published this metabolomics dataset on figshare in May 2026. The data likely contains results from a near genome-wide screen and metabolomic analysis of fungal adaptation.

Use Cases

• Identify genetic determinants of CO2 tolerance based on fitness scores for 301 mutants.
• Analyze remodeling of central carbon metabolism based on metabolomic data mentioned in the description.
• Investigate the role of oxidative stress buffering and membrane homeostasis in fungal virulence.
• Model the integrated response to CO2 stress mediated by the TOR-Ypk1 signaling axis.
• Study the link between CO2-induced capsule formation and cellular glucose utilization.

Strengths

• The dataset is derived from a near genome-wide screen of 4,692 deletion mutants.
• It includes metabolomic analysis, providing a multi-faceted view of fungal adaptation.
• The data is published under a CC-BY-4.0 license, facilitating open reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is 78.3 KB, indicating a limited scope and likely summary-level results.

Provenance

Source

figshare

Collection Method

Competitive growth assay and metabolomic analysis.

Freshness

Last updated 2026-05-05 17:37:23; freshness should be verified.