METABRIC: Validation of Hypoxia Score, CNA Burden, and Survival Associations

A validation dataset from the METABRIC breast cancer cohort examining associations among a 16-gene hypoxia score, copy number alteration (CNA) burden, and overall survival. The 5.5 KB Excel file was authored by Wenhan Yang and last updated on June 2, 2026. It is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Validate a 16-gene hypoxia signature's association with clinical outcomes based on the description.
• Assess the relationship between copy number alteration burden and overall survival in breast cancer.
• Perform secondary analysis on the interplay between hypoxia and genomic instability in the METABRIC cohort.

Strengths

• Dataset is small (5.5 KB), facilitating quick download and inspection.
• Explicitly validates associations among three key molecular/clinical variables: a 16-gene hypoxia score, CNA burden, and overall survival.
• Has a clear, permissive license (CC-BY-4.0).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, authored by Wenhan Yang.

Collection Method

Likely derived from analysis of the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) cohort.

Freshness

Last updated 2026-06-02 17:34:10; freshness should be verified.