Minimal Dataset: Molnupiravir Efficacy and Uridine Cytidine Kinase Activity

A 2.0 MB dataset in XLSX format, uploaded by Huazhang Shu to figshare and last updated on 2026-05-29. It contains data related to the antiviral drug molnupiravir and its interaction with host enzymes. The description suggests the data underpins research on uridine cytidine kinases (UCK1 and UCK2) and their role in the drug's bioactivation and anti-SARS-CoV-2 efficacy.

Use Cases

• Modeling the relationship between UCK enzyme activity and molnupiravir's antiviral efficacy based on the described biochemical assays.
• Analyzing the structural basis of NHC phosphorylation using data from the UCK1-NHC-AMPPNP co-crystal structure mentioned in the description.
• Investigating the impact of UCK2 knockdown on intracellular antiviral metabolite levels, as suggested by the siRNA experiment results.
• Evaluating dose-response relationships for UCK inhibitors and their effect on drug selectivity, as indicated in the description.

Strengths

• File size is precisely 2.0 MB, indicating a manageable download.
• License is clearly specified as CC-BY-4.0, permitting broad reuse with attribution.
• Last update timestamp is provided (2026-05-29 18:00:44).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The description is detailed but focuses on research findings; the exact data variables are not enumerated.

Provenance

Source

Huazhang Shu via figshare.

Collection Method

Likely contains experimental data from in vitro assays, crystallography, and cell-based studies as described.

Freshness

Last updated 2026-05-29 18:00:44; freshness should be verified.