Economic Model Inputs for Liver Fibrosis Screening in Thailand

Figshare hosts a dataset containing input parameters for a lifetime economic model evaluating liver fibrosis screening strategies in Thai adults with metabolic syndrome or obesity. The data supports a cost-utility and 5-year budget impact analysis comparing three screening methods against no screening. Inputs were derived from literature review and primary data analysis, with results discounted at 3% annually.

Use Cases

• Calibrate the lifetime economic model using inputs for quality-adjusted life years (QALYs) and costs from a societal perspective.
• Perform probabilistic sensitivity analysis using the provided input parameters to assess the robustness of incremental cost-effectiveness ratios (ICERs).
• Replicate the 5-year budget impact analysis from the payer perspective using the cost and population inputs.
• Analyze the influence of specific model inputs, such as the transition probability from fibrosis stage F3 to F4, on the calculated ICERs.
• Validate the cost-effectiveness findings for screening strategies like FIB-4 followed by transient elastography against the 160,000 THB willingness-to-pay threshold.

Strengths

• Model inputs are grounded in a specific published study, providing context for the cost-utility analysis.
• Data supports a detailed economic evaluation from both societal and payer perspectives over a 5-year budget horizon.
• Inputs enable sensitivity analyses, with the study reporting cost-effectiveness probabilities ranging from 59% to 78%.

Limitations

• The dataset is very small at 82.0 KB, containing only model parameters without underlying patient-level or trial data.
• Data scope is limited to the specific context of Thailand and the defined screening strategies, reducing generalizability.
• As model inputs, the data requires significant domain expertise in health economics for proper application and interpretation.

Provenance

Source

Figshare, authored by Chayanis Kositamongkol.

Collection Method

Derived from literature review and primary data analysis for an economic modeling study.

Time Range

null

Freshness

null

Geography

Thailand