Model Stability Assessment: 11 Genetic Loci for Age-Related Eye Disease

A genetic analysis dataset containing results from Genomic Structural Equation Modeling and post-processing of Genome-Wide Association Studies for Age-related eye disease (ARED). The dataset, authored by Luqi Gao and last updated in May 2026, identifies 11 genome-wide significant loci and includes transcriptome-wide association signals across tissues and cell layers. It presents a genetic landscape for a phenotype not directly measured.

Use Cases

• Prioritizing candidate SNPs for Age-related eye disease based on Genomic-SEM results
• Analyzing tissue- and cell layer-specific gene signals from transcriptome-wide association studies
• Functional annotation of genetic variants associated with age-related ocular vulnerabilities
• Replicating the identification of 11 genome-wide significant loci for ARED

Strengths

• Identifies 11 genome-wide significant loci for Age-related eye disease
• Applies multiple analysis methods including Genomic-SEM and diverse transcriptome-wide association approaches
• Released under a permissive CC-BY-4.0 license

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download

Provenance

Source

figshare

Collection Method

Genomic Structural Equation Modeling and post-processing analysis of Genome-Wide Association Studies

Freshness

Last updated 2026-05-14 17:48:42; freshness should be verified