MALDI-TOF MS Protein Profiles of Schistosoma-Infected Snails

Protein mass spectrometry data from a study using MALDI-TOF MS to differentiate Schistosoma mansoni-infected Biomphalaria snails from uninfected ones. The dataset includes profiles for two snail species, Biomphalaria pfeifferi and Biomphalaria glabrata, analyzed via principal component analysis. Specific discriminating spectral peaks were identified for each species based on infection status.

Use Cases

• Train a classifier using spectral peak intensity data to predict S. mansoni infection status in Biomphalaria snails.
• Apply principal component analysis (PCA) to MALDI-TOF MS protein profiles to visualize clustering of infected versus uninfected snail groups.
• Identify specific discriminating peaks in mass spectrometry data that are characteristic of infection for each snail species (Biomphalaria pfeifferi and Biomphalaria glabrata).
• Compare protein profile changes, such as peak number and intensity increases, between laboratory-strain and field-collected snails post-infection.

Strengths

• Data generated from a controlled laboratory infection study with confirmation via cercariae emission tests and quantitative PCR (qPCR).
• Analysis includes two distinct snail species, Biomphalaria pfeifferi (field-collected) and Biomphalaria glabrata (laboratory strain), allowing for cross-species comparison.
• Application of principal component analysis (PCA) to mass spectrometry profiles provides a validated method for group discrimination.

Limitations

• The dataset is very small at 5.5 KB, indicating limited sample size and scope for machine learning applications.
• Data is from a single experimental study; results may not generalize to other snail populations or Schistosoma strains without further validation.
• The methodology note that field application requires standardization of sample collection and preparation, which is not yet established.

Provenance

Source

Figshare, authored by Diara Sy.

Collection Method

MALDI-TOF mass spectrometry analysis of protein profiles from snails infected in the laboratory with S. mansoni miracidia.

Freshness

Last updated in March 2026.

Geography

Snails collected in Senegal (Biomphalaria pfeifferi); laboratory strain (Biomphalaria glabrata).