Mouse Prion Protein Expression Levels Normalized to Wild-Type

Mouse lines used in a specific study, with PrP expression levels measured in whole hemisphere. Expression data is normalized to wild-type animals (1.0x = wild-type expression) and includes lines maintained on a homozygous ZH3/ZH3 PrP knockout background. The dataset was authored by Taylor L. Corridon and last updated in May 2026.

Use Cases

• Compare relative PrP expression levels across different mouse genetic lines based on normalized values.
• Analyze the impact of specific genetic backgrounds (e.g., ZH3/ZH3 knockout) on protein expression.
• Study the relationship between PrP sequence alleles (MoPrP-A vs. MoPrP-B) and measured expression levels.
• Validate or correlate expression measurements from different assay methods (ELISA vs. MRM) mentioned in the description.

Strengths

• Expression levels are normalized to a wild-type baseline (1.0x), providing a standardized comparison.
• Includes specific genetic background details, such as homozygous ZH3/ZH3 PrP knockout.
• Data originates from a published scientific study, suggesting a research context.

Limitations

• The dataset is very small (5.5 KB), indicating limited scope and likely few records.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Expression levels measured by in-house ELISA or IQ Proteomics MRM assay.

Freshness

Last updated 2026-05-26 17:34:07; freshness should be verified.