Multivariable Analyses of PFS-Related Factors in Second-Line uHCC Therapy

81 patients with unresectable hepatocellular carcinoma were analyzed in a retrospective, non-randomized comparative study. The dataset compares second-line durvalumab plus tremelimumab (n=14) versus lenvatinib (n=67) after first-line atezolizumab plus bevacizumab, assessing progression-free survival, overall survival, adverse events, and ALBI score changes. Chinatsu Nishioka uploaded this 9.5 KB Excel file to figshare in May 2026.

Use Cases

• Compare progression-free survival (PFS) and overall survival (OS) between two second-line treatment regimens based on the described patient groups.
• Analyze the relationship between neutrophil-to-lymphocyte ratio and overall survival outcomes based on the multivariable analysis results.
• Assess adverse event frequency and severity differences between immunotherapy and targeted therapy based on the reported grade ≥3 AE rates.
• Model changes in liver function using the albumin–bilirubin (ALBI) score over time based on the week 4 measurements.
• Identify independent predictors of longer PFS and worse OS based on the multivariable analysis factors mentioned.

Strengths

• Includes real-world data from a prospectively registered observational cohort of 81 patients.
• Compares two specific second-line therapies with detailed metrics: median PFS (1.7 vs. 4.2 months), median OS (5.3 vs. 14.0 months), and objective response rates (7.7% vs. 23.3%).
• Reports specific adverse event frequencies (70.1% vs. 21.4% grade ≥3 AEs) and quantitative ALBI score changes.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The study is retrospective and non-randomized, which may introduce selection bias.

Provenance

Source

figshare, author Chinatsu Nishioka

Collection Method

Retrospective analysis of real-world data from a prospectively registered observational cohort.

Time Range

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Freshness

Last updated 2026-05-07 18:00:16; freshness should be verified.

Geography

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