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Description
A multi-centre observational study integrates clinical and molecular data from neonates with moderate to severe hypoxic-ischaemic encephalopathy and healthy term controls. The dataset includes planned whole genome sequencing, DNA methylation, RNA-seq, proteomic, metabolomic, placental microbiome, and histopathological analyses. Carina C. Babbo authored this dataset, last updated in April 2026.
Use Cases
Identify clinical risk factors associated with NESHIE by analyzing integrated clinical data fields from patient records.
Detect genetic variants relevant to disease susceptibility through analysis of whole genome sequencing data.
Assess epigenetic influences by examining DNA methylation patterns from bisulfite sequencing results.
Characterize proteomic and metabolomic profiles from dried blood spot samples using liquid chromatography–mass spectrometry data.
Evaluate placental histopathological differences and microbiome composition between case and control groups.
Strengths
Multi-dimensional data integration across 7 distinct molecular and clinical analysis platforms.
Ethically approved multi-centre study design with registrations in Gauteng and Western Cape, South Africa.
Dataset is openly shared under a CC-BY-4.0 license.
Limitations
The dataset is very small at 5.5 KB, indicating it likely contains metadata or a data dictionary rather than the full multi-omics results.
Specific row counts, column names, and sample data are unavailable, limiting immediate analytical utility.
The temporal coverage and final participant counts from the observational study are not specified in the metadata.
Provenance
Source
figshare, authored by Carina C. Babbo.
Collection Method
Multi-centre observational study integrating clinical examinations with planned multi-omics assays.
Time Range
null
Freshness
Last updated in April 2026, indicating planned or ongoing data collection.
Geography
South African cohort from Gauteng and Western Cape provinces.
The 5.5 KB XLS file likely describes the study protocol or data dictionary; the actual multi-omics data files are not included in this specific upload.