MRD Threshold NRI Analysis: Comparing 0.05% vs 0.1% at End of Course 1

Net reclassification improvement analysis compares a new minimal residual disease threshold of 0.05% to a traditional 0.1% threshold. The 5.5 KB Excel file contains results from a multivariable model comparison, with statistical significance assessed via 1,000 bootstrap iterations. Authored by Xiong-yu Liao and last updated in May 2026, it is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Compare model performance based on net reclassification improvement for different MRD thresholds.
• Assess statistical significance of NRI using bootstrap confidence intervals as described.
• Evaluate the impact of lowering the MRD detection threshold from 0.1% to 0.05% in a clinical context.

Strengths

• Statistical significance is rigorously assessed using bootstrap resampling with 1,000 iterations.
• The dataset is shared under a permissive CC-BY-4.0 license, facilitating reuse.
• A specific comparison between two defined MRD thresholds (0.05% and 0.1%) is the core focus.

Limitations

• Row count is unknown, which may limit suitability assessment for certain analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• The description metadata is limited to the core analysis, with no details on the underlying patient data.

Provenance

Source

figshare

Collection Method

Likely derived from a clinical study analyzing minimal residual disease thresholds.

Freshness

Last updated 2026-05-08 17:28:11; freshness should be verified.