Net Reclassification Improvement Analysis for MRD Thresholds

A statistical analysis dataset comparing the net reclassification improvement (NRI) of a new minimal residual disease (MRD) threshold (0.05%) against a traditional threshold (0.1%) at the end of treatment course 2. The dataset, authored by Xiong-yu Liao and shared on figshare, contains results from a multivariable model comparison with significance assessed via bootstrap resampling (1,000 iterations). It was last updated on May 8, 2026.

Use Cases

• Evaluate the performance improvement of a new diagnostic threshold based on NRI metrics.
• Assess statistical significance of classification changes using bootstrap confidence intervals.
• Compare multivariable prognostic models for minimal residual disease.
• Validate a lower MRD detection threshold for clinical decision-making.

Strengths

• Statistical significance assessed with a rigorous method: bootstrap resampling using 1,000 iterations.
• Clear comparison defined between two specific MRD thresholds: 0.05% and 0.1%.
• Published under a permissive CC-BY-4.0 license, allowing reuse with attribution.

Limitations

• Description metadata is limited; actual data quality and structure require manual inspection after download.
• Row count and column-level documentation are absent; field semantics must be inferred from the XLS file.
• The 5.5 KB file size indicates a very small dataset, likely containing summary statistics rather than raw patient data.

Provenance

Source

figshare

Collection Method

Analysis output from a multivariable model comparison with bootstrap resampling.

Time Range

Analysis timeframe is not specified.

Freshness

Last updated 2026-05-08 17:28:12; freshness should be verified.

Geography

Geographic scope is not specified.