Neurobehavioral Deficit Scores in Intracerebral Hemorrhage Mouse Model

11.6 KB Excel file contains neurobehavioral and histological data from a study on GABAAR modulators in a mouse model of intracerebral hemorrhage. The dataset, created by Tingting Chen, compares outcomes for mice treated with CL218872 or MRK-016 against controls. It includes scores for neurological deficits, inflammation markers, and synaptic protein expression.

Use Cases

• Compare neurological deficit scores between CL218872-treated, MRK-016-treated, and control mouse groups to assess therapeutic efficacy.
• Analyze correlations between inflammation markers like phospho-p65, IL-6, and TNF-α expression and neurobehavioral outcomes.
• Investigate relationships between synaptic plasticity molecules (BDNF, GAP-43, PSD-95, synaptophysin) and histological measures of neuronal density or synaptic connectivity.

Strengths

• Data originates from a controlled preclinical study with defined treatment groups (CL218872, MRK-016, control).
• Includes multiple measurement types: behavioral scores (neurological deficit), molecular markers (inflammatory cytokines, synaptic proteins), and histological assessments (neuronal density, synaptic structure).
• Shared under a permissive CC BY 4.0 license, allowing for reuse and redistribution.

Limitations

• Very small data volume (11.6 KB), indicating a limited sample size likely from a single laboratory experiment.
• No column names or sample data provided, making initial data exploration and schema understanding difficult.
• Data is specific to a collagenase IV-induced mouse model, limiting direct translation to human intracerebral hemorrhage.

Provenance

Source

Figshare, authored by Tingting Chen.

Collection Method

Generated from a controlled laboratory study using a collagenase IV-induced intracerebral hemorrhage mouse model, with treatments administered and outcomes measured histologically and behaviorally.

Freshness

Last updated March 23, 2026.