Neutrophil Subsets from Children with Malaria Exposure and Burkitt Lymphoma in Kenya

A prospective study profiling neutrophil subsets from children with different Plasmodium falciparum malaria exposure histories and children diagnosed with Burkitt lymphoma in Western Kenya, along with healthy malaria low-exposed Kenyan adults. Data was collected using multiparameter flow cytometry, characterizing neutrophils by expression of CD15, CD16, CD10, CD11b, CD182, CD184, and CD62L. The dataset, authored by Sharon Akinyi Okoth and last updated on 2026-06-01, is shared under a CC-BY-4.0 license.

Use Cases

• Analyzing correlations between malaria exposure and frequencies of aged versus mature neutrophil subsets based on flow cytometry data.
• Investigating the potential link between immature neutrophil expansion and Burkitt lymphoma tumorigenesis suggested by the study's findings.
• Profiling immune cell phenotypes in pediatric populations from sub-Saharan Africa with different infectious disease histories.
• Validating flow cytometry gating strategies for neutrophil subsets defined by CD15, CD16, CD10, CD11b, CD182, CD184, and CD62L markers.

Strengths

• Includes data from a specific, clinically relevant cohort: children with malaria exposure and Burkitt lymphoma from Western Kenya.
• Provides multiparameter flow cytometry data for seven specific surface markers (CD15, CD16, CD10, CD11b, CD182, CD184, CD62L).
• Dataset is openly shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is very small at 21.1 KB, indicating limited scope and likely a small sample size.
• Row count and column-level documentation are unknown, requiring manual inspection after download to understand data structure.
• Functional assay data is absent, as noted in the description, limiting direct mechanistic conclusions.

Provenance

Source

figshare, author Sharon Akinyi Okoth.

Collection Method

Prospective study using multiparameter flow cytometry.

Freshness

Last updated 2026-06-01 17:49:19.

Geography

Western Kenya.