SLFN14 Variant Effects on tRNA Cleavage and Translation in HEK293T Cells

Numeric values extracted from graphs in a study on Schlafen protein 14 (SLFN14). The data likely contains measurements related to tRNA cleavage, ribosome stalling, and protein synthesis in HEK293T cells expressing human SLFN14 variants. The dataset was authored by Chengchao Ding and last updated on 2026-05-29.

Use Cases

• Analyze the impact of SLFN14 variants on global protein synthesis based on the described translational repression.
• Model the relationship between tRNA cleavage specificity and ribosome stalling based on the described shift in RNA substrate targeting.
• Investigate the link between altered RNA targeting by SLFN14 and cell death signaling pathways based on the described stress response.

Strengths

• Data is directly linked to a specific published biological mechanism involving SLFN14 and tRNA cleavage.
• The dataset is small (51.0 KB), facilitating quick download and initial inspection.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely extracted from experimental figures in the associated research.

Freshness

Last updated 2026-05-29 17:44:11; freshness should be verified.