Cryptococcus Neoformans CO2 Tolerance Genetic Screen and Metabolomic Data

A 258.6 KB Excel file containing numerical data for all figures from a study on Cryptococcus neoformans adaptation to host CO2 levels. The data includes results from a near genome-wide screen of 4,692 deletion mutants, identifying 301 with altered CO2 fitness, and supporting metabolomic analysis. It was authored by Laura C. Ristow and last updated on May 5, 2026.

Use Cases

• Identifying genetic determinants of CO2 tolerance based on the competitive growth assay of deletion mutants.
• Modeling the integrated stress response involving central carbon metabolism and membrane homeostasis based on the metabolomic analysis.
• Investigating the role of the TOR-Ypk1 signaling axis in fungal adaptation to host conditions.

Strengths

• Data is derived from a near genome-wide screen of 4,692 deletion mutants, providing a broad genetic profile.
• Includes results from both a genetic screen (301 mutants with altered fitness) and a metabolomic analysis, offering multi-modal insights.
• Published under a permissive CC-BY-4.0 license, facilitating reuse and sharing.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• The 258.6 KB file size indicates a limited, study-specific dataset rather than a large-scale resource.

Provenance

Source

figshare

Collection Method

Data generated from a competitive growth assay genetic screen and metabolomic analysis of Cryptococcus neoformans.

Freshness

Last updated 2026-05-05 17:37:28; freshness should be verified.