P2X3 Receptor Electrophysiology and Structural Analysis Data

Zhixuan Zhao published this dataset on figshare in April 2026. It contains numerical raw data supporting a study on the human P2X3 receptor and its inhibition by the investigational drug sivopixant. The data likely includes results from structure-based mutational analysis by electrophysiology and molecular dynamics simulations.

Use Cases

• Analyzing the allosteric inhibition mechanism of P2X3 receptors based on cryo-EM structural data.
• Correlating specific mutations with drug sensitivity based on patch-clamp electrophysiology results.
• Comparing subtype selectivity of negative allosteric modulators based on structural comparisons across P2X subtypes.

Strengths

• Data is associated with a peer-reviewed structural biology study published on figshare.
• The dataset is licensed under CC-BY-4.0, allowing for broad reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (505.5 KB), indicating a limited scope of raw data.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from cryo-EM, electrophysiology, and molecular dynamics simulations.

Freshness

Last updated 2026-04-22 17:40:08; freshness should be verified.