One-Dose Screening in Malignant Cells (SW480): Cytotoxicity and Molecular Docking Data

A dataset from a study evaluating novel benzofuran-pterostilbene hybrid molecules against colorectal adenocarcinoma cells. The data includes GI50 values for compounds 6d and 6e, results from Hoechst 33342 imaging, wound-healing assays, and molecular docking simulations with mutant p53, CDK4, and PARP-1 proteins. The dataset was authored by Angie Herrera-Ramírez and last updated on 2026-04-13.

Use Cases

• Compare cytotoxic potency based on reported GI50 values for hybrid compounds.
• Analyze cell death mechanisms based on fluorescence imaging results described.
• Validate molecular docking predictions against mutant p53, CDK4, and PARP-1 protein targets.
• Assess cell migration inhibition using data from wound-healing assays mentioned.
• Model pharmacokinetic and toxicological profiles of benzofuran-pterostilbene scaffolds.

Strengths

• Includes specific, measured GI50 values (e.g., 4.74 ± 0.38 µM for compound 6e).
• Data is derived from multiple experimental methods: cytotoxicity assays, fluorescence imaging, flow cytometry, and molecular docking.
• Dataset is shared under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 5.5 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Experimental results from synthesized compounds tested on SW480 colon cancer cells.

Time Range

The study period is not specified.

Freshness

Last updated 2026-04-13 17:27:32; freshness should be verified.

Geography

Geographic origin of the data is not specified.