Gene Expression Data for Lupus Nephritis Hub Genes

Yu Sun published a bioinformatics dataset on figshare in March 2026. The dataset likely contains gene expression data from the GEO dataset GSE32591, used to identify hub genes like GBP2 in pediatric lupus nephritis. The 52.7 KB Excel file includes results from in vivo and in vitro analyses of GBP2's role in pyroptosis.

Use Cases

• Validate hub gene identification based on differential expression analysis mentioned in the description
• Correlate gene expression levels with clinical markers like 24-hour urinary protein excretion
• Investigate the relationship between GBP2 expression and pyroptosis-associated proteins (GSDMD, AIM2)
• Model the regulatory mechanism of GBP2 on inflammatory cytokine secretion (IL-1β, IL-18)

Strengths

• Dataset is openly licensed under CC-BY-4.0
• Analysis is based on a publicly available GEO dataset (GSE32591)
• Includes results from both in vivo (mouse model) and in vitro (podocyte model) experiments

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small (52.7 KB), suggesting limited scope

Provenance

Source

figshare

Collection Method

Bioinformatics analysis of the GEO dataset GSE32591, supplemented by immunohistochemistry, RT-qPCR, and western blotting experiments.

Freshness

Last updated 2026-03-19 17:22:24; freshness should be verified