Original Data for Figures in a Study on THY1 in DSS-Induced Colitis

A 28.9 MB dataset containing the original data used to generate figures for a study investigating the role of the angiogenesis-related target THY1 in dextran sulfate sodium (DSS)-induced acute colitis in mice. The data was authored by Pengliang Zhang and last updated on June 2, 2026. The study utilized lentivirus-based knockdown and overexpression systems in a mouse model and co-culture system.

Use Cases

• Validate the reported effects of THY1 on inflammatory response and oxidative stress levels in DSS-induced colitis.
• Re-analyze the relationship between THY1 expression and M2 macrophage polarization described in the mechanism research.
• Investigate the correlation between THY1 and angiogenesis markers HIF-1α and VEGF expression.
• Examine the role of THY1 in intestinal epithelial cell apoptosis via the Bcl-2/Bax/Cleaved caspase-3 pathway.

Strengths

• Data is directly linked to a specific published study with a detailed methodological background.
• Available under a permissive CC-BY-4.0 license for reuse and redistribution.
• File size is 28.9 MB, indicating a contained and likely manageable dataset.

Limitations

• Row count and specific column names are unknown, limiting pre-download assessment of data structure and scale.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is focused on a specific mouse model (DSS-induced), which may limit direct translation to human IBD studies.

Provenance

Source

Pengliang Zhang, via figshare.

Collection Method

Data generated from a study using lentivirus-based systems for gene manipulation in a DSS-induced mouse colitis model and co-culture systems.

Freshness

Last updated 2026-06-02 17:22:57; freshness should be verified.