Original Data Sets: Oxfendazole Efficacy Against Filarial Larvae in Mice

Oxfendazole treatment for 5 days led to a 97.6% median reduction in worm count in a preclinical mouse model. The data, published by Frederic Risch on figshare in 2026, supports the repurposing of this veterinary anthelmintic for human filarial infections. It contains results from a study investigating the drug's efficacy against the infective larval stage of Litomosoides sigmodontis.

Use Cases

• Modeling dose-response relationships based on the reported dose-dependent reduction in recovered worms.
• Analyzing treatment duration efficacy based on the comparison of 3-day and 5-day regimens.
• Assessing worm morphology impact based on the reported reduction in the length of isolated worms.
• Supporting preclinical data for clinical trial design based on the strong activity against adult and larval stages.

Strengths

• Data underpins a key finding: a 97.6% median worm clearance rate with a 5-day treatment.
• Results show a dose-dependent effect, with up to 82.6% reduction from a 3-day regimen.
• Shared under a permissive CC-BY-4.0 license for open reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 21.9 KB file size indicates a very limited data scope.

Provenance

Source

Frederic Risch via figshare.

Collection Method

Experimental data from a preclinical study in BALB/cJ mice, with worms assessed ex vivo 35 days after infection.

Time Range

Study period not specified; dataset last updated in 2026.

Freshness

Last updated 2026-04-21 17:48:51; freshness should be verified.

Geography

Laboratory study; geographic origin not specified.