Parameter Ranges for Morris Screening of a Combined HPA and SA Axis Stress Model

Parameter ranges for a Morris screening sensitivity analysis of a differential equation-based model. The model combines the hypothalamic-pituitary-adrenal (HPA) and sympathoadrenal (SA) axes to simulate cortisol and catecholamine dynamics under acute physical stress. The dataset was authored by Helen A. Harris and last updated on March 24, 2026.

Use Cases

• Conducting sensitivity analysis on a combined HPA and SA axis model based on the described differential equations.
• Estimating model parameters via constrained optimization based on time series data of cortisol and catecholamines.
• Validating subject-specific parameter estimation for models of acute stress response.
• Comparing model outputs with collected data for qualitative agreement assessment.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• File size is 5.5 KB, indicating a focused and manageable dataset.
• Model parameters were estimated with respect to time series data of cortisol and catecholamine dynamics.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Helen A. Harris via figshare

Collection Method

Parameters derived from sensitivity analysis (Morris screening) and constrained optimization of a mathematical model.

Time Range

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Freshness

Last updated 2026-03-24 17:36:27; freshness should be verified.

Geography

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