HPA and SA Axis Model Parameters for Acute Stress Response

Parameter values for a differential equation model simulating the hypothalamic-pituitary-adrenal (HPA) and sympathoadrenal (SA) axes. The data supports a combined mathematical model of hormonal stress response, estimated using time series data of cortisol and catecholamine dynamics under acute physical stress. The dataset is provided by author Helen A. Harris.

Use Cases

• Calibrate the differential equation model using the estimated parameters to simulate cortisol and catecholamine dynamics.
• Perform sensitivity analysis on the model parameters to identify key drivers of the acute stress response.
• Validate the combined HPA and SA axis model against new experimental time series data for cortisol.

Strengths

• Parameters are derived from constrained optimization with respect to experimental time series data.
• Model includes the combined effects of the HPA and SA axes, a novel extension of prior work.
• Data is openly shared under a CC BY 4.0 license.

Limitations

• The dataset is very small at 5.5 KB, indicating a limited set of parameters or model outputs.
• No raw time series data or model code is included, only the final parameters.
• The model's applicability is specific to acute physical stress scenarios.

Provenance

Source

Helen A. Harris via figshare.

Collection Method

Parameters estimated via constrained optimization using time series data of cortisol and catecholamines.

Time Range

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Freshness

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Geography

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