Participants’ Characteristics for a Childhood Obesity Genetic Study in Guangzhou

Xiaotong Liang published a dataset on figshare in 2026. It contains participant characteristics from a case-control study of 1123 children and adolescents with obesity and 1231 controls from Guangzhou, China. The data supports an investigation into genetic variants in the leptin-melanocortin pathway and their interaction with lifestyle factors.

Use Cases

• Constructing genetic risk scores based on variants in MC4R, LEPR, and POMC genes.
• Analyzing associations between specific genetic variants and childhood obesity risk.
• Investigating gene-lifestyle interactions, specifically with physical activity and sleep duration.

Strengths

• Dataset includes 2354 total participants (1123 cases, 1231 controls), providing a substantial sample size for analysis.
• Focuses on twelve potentially functional genetic variants in a specific biological pathway (leptin-melanocortin).
• Data is structured for analysis of gene-lifestyle interactions using established statistical measures (RERI, AP, IOR).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to a single-city (Guangzhou) study.

Provenance

Source

Xiaotong Liang via figshare.

Collection Method

Frequency-matched case-control study with genotyping of twelve genetic variants.

Freshness

Last updated 2026-05-15 17:53:30; freshness should be verified.

Geography

Guangzhou, China.