IMTU: Pharmacokinetic and Analgesic Properties of a TRPV1 Antagonist in Mice

Pharmacokinetic properties of the novel TRPV1 antagonist IMTU in mice, authored by Jialiang Guan and last updated in March 2026. The dataset is 5.5 KB in size and is available in XLS format. It is licensed under CC-BY-4.0 and hosted on figshare.

Use Cases

• Modeling dose-response relationships based on the reported IC50 value of 128.34 ± 9.49 nM.
• Analyzing the effect of IMTU on channel open probability based on the reduction from 80.8% to 14.9%.
• Evaluating analgesic efficacy in preclinical models based on results from formalin and CFA-induced inflammatory pain tests.
• Studying drug selectivity based on the description of no inhibition of cardiotoxicity-related channels.

Strengths

• Includes specific quantitative results, such as an IC50 value of 128.34 ± 9.49 nM.
• Reports detailed experimental outcomes, like the reduction of channel open probability from 80.8% to 14.9%.
• Licensed under the permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 5.5 KB, indicating limited scope.

Provenance

Source

Jialiang Guan via figshare

Collection Method

Likely contains data from whole-cell patch clamp, single-channel recording, and in vivo pain model assays described in the study.

Freshness

Last updated 2026-03-25 17:34:09; freshness should be verified.