Eclampsia Prodromal Symptoms Case-Control Study in South Africa and Pakistan

Roxanne Hastie published a dataset on figshare in 2026 containing primary data from a case-control study of 341 participants with eclampsia, 1,355 with preeclampsia, and 389 with normotensive pregnancies. The data includes survey responses on 20 neurological symptoms experienced within 7 days of a seizure for eclampsia cases, with statistical analysis of odds ratios for symptom associations. The study aimed to identify new prodromal symptoms of eclampsia to improve risk assessment and guide magnesium sulphate prophylaxis.

Use Cases

• Training predictive models for eclampsia risk based on reported neurological symptom profiles.
• Analyzing the association strength between specific prodromal symptoms (e.g., twitching limbs, affected hearing) and eclampsia versus preeclampsia.
• Validating clinical screening tools by comparing the predictive power of traditional symptoms (headache, visual disturbances) against newly identified high-odds-ratio symptoms.

Strengths

• Includes data from 2,085 total participants (341 eclampsia, 1,355 preeclampsia, 389 normotensive).
• Reports specific odds ratios with confidence intervals for 20 neurological symptoms, including 10 with odds ratios over 10.
• Data collection was prospective and involved two distinct geographic regions (South Africa and Pakistan).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The study design is susceptible to recall bias as symptoms were asked about after the seizure occurred.

Provenance

Source

Roxanne Hastie via figshare

Collection Method

Prospective case-control study with participant surveys.

Freshness

Last updated 2026-04-28 17:21:32; freshness should be verified.

Geography

South Africa and Pakistan