219 Complete Neisseria Gonorrhoeae Genomes for Opa Gene Analysis

219 complete genomes of the sexually transmitted pathogen Neisseria gonorrhoeae were assembled using long-read sequencing to resolve the multiple copies of opacity-associated (Opa) genes. The dataset, created by QinQin Yu and last updated in May 2026, reveals that Opa genes are on average 74 times more diverse than the rest of the genome. Each genome contains an average of 7 distinct opa alleles across 9–12 loci, with fewer genes in frame than expected by chance.

Use Cases

• Study Opa gene diversity and evolution based on the resolved complete genomes.
• Analyze allele sequence similarity and genomic distance correlations described in the study.
• Investigate reading frame patterns and expression inference of Opa genes.
• Compare evolutionary rates between different Opa loci identified in the data.
• Assess the role of interspecies recombination in antigen diversity.

Strengths

• Contains 219 complete genomes from phylogenetically diverse clinical isolates.
• Uses long-read sequencing to resolve multiple opa gene copies, overcoming a key limitation of short-read methods.
• Includes quantitative bioinformatics and phylogenetics tools developed for the analysis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 24.2 KB, indicating limited scope.

Provenance

Source

figshare, author QinQin Yu.

Collection Method

Long-read sequencing assembly of clinical isolates.

Freshness

Last updated 2026-05-11 17:46:59; freshness should be verified.