Rabbit Model Data on Maternal Undernutrition and Offspring Development

María Arias-Alvarez's 2026 study provides experimental data from a rabbit model investigating maternal food restriction effects. The dataset captures body composition, metabolic profiles, and gene expression markers in F1 and F2 offspring from birth to sexual maturity at 16 weeks. It includes serum aminotransferase levels, progesterone/estradiol ratios, and mRNA expression data for genes like SOD2 and TP53.

Use Cases

• Analyze correlations between maternal diet group (Control vs. FR) and serum aminotransferase levels in F1 females to assess hepatic stress.
• Model the impact of the progesterone/estradiol ratio at ovulation time on the proportion of expanded blastocysts in F2 embryos.
• Compare mRNA expression levels of SOD2, G6PD, and FABP4 in F2 oocytes between dietary groups to study oxidative stress and fatty acid uptake.
• Examine growth trajectory and body composition data from birth to 16 weeks to evaluate long-term metabolic impacts of maternal undernutrition.

Strengths

• Data originates from a controlled experimental study with defined Control and Food Restricted (FR) groups.
• Includes multi-generational measurements on F0 mothers, F1 offspring, and F2 oocytes/embryos.
• Captures a longitudinal time range from birth to sexual maturity at 16 weeks.
• Released under a permissive CC BY 4.0 license for reuse.

Limitations

• Dataset is very small at 26.7 KB, indicating limited scope and likely a low row count.
• Data is specific to the rabbit model, limiting direct applicability to human or other mammalian studies.
• Lacks explicit column definitions and sample data, requiring careful interpretation of the provided XLSX file.

Provenance

Source

María Arias-Alvarez via figshare.

Collection Method

Data generated from a controlled animal experiment where pregnant rabbits (F0) were fed either ad libitum or a restricted diet covering 60% of nutritional requirements.

Time Range

Covers from gestation through offspring development to sexual maturity at 16 weeks.

Freshness

Last updated March 2026.

Geography

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