Echinococcus Multilocularis Gene Expression Data Supporting Manuscript

Alveolar echinococcosis research data from a study on canonical WNT signaling's role in parasite body-axis formation. The dataset contains gene expression results from RNAi-mediated knockdown experiments targeting the β-catenin gene (bcat-1) in Echinococcus multilocularis cell cultures. It supports findings on stem-cell hyperproliferation, muscle-fibre organisation changes, and transcriptomic shifts.

Use Cases

• Analyze gene expression changes for markers like sfrp, frizzled-10, and notum following bcat-1 knockdown to study anteriorization.
• Investigate downregulation of metacestode-specific genes such as muc-1, TNFR, and post2b in relation to vesicle-formation defects.
• Correlate transcriptomic profiles with phenotypic observations of stem-cell hyperproliferation and muscle-fibre organisation from the primary cell culture system.

Strengths

• Data is directly associated with a peer-reviewed scientific manuscript, providing clear research context.
• Includes genome-wide transcriptomics data revealing expression changes for numerous genes like antigen B and nou-darake.
• Released under the permissive CC BY 4.0 license, facilitating reuse and distribution.

Limitations

• The dataset is very small at 18.4 KB, indicating limited scope, likely containing only summary or key result tables.
• No column names or sample data are provided, making the exact data structure and variables unknown.
• Data is specific to a single experimental study on Echinococcus multilocularis, limiting generalizability to other organisms or conditions.

Provenance

Source

Ruth Herrmann via figshare.

Collection Method

Generated from RNAi experiments and transcriptomic analysis on a primary Echinococcus multilocularis parasite cell culture system.

Time Range

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Freshness

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Geography

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