Mouse Intracerebral Hemorrhage Neurorestoration Experimental Data

Mouse model data from in vivo experiments assessing neurorestorative effects of GABAAR modulators CL218872 and MRK-016 following induced intracerebral hemorrhage. The dataset includes measurements of inflammation markers, neurological deficit scores, and synaptic plasticity molecules. It was authored by Tingting Chen and shared under a CC BY 4.0 license.

Use Cases

• Analyze differences in inflammation markers like phospho-p65, IL-6, and TNF-α expression between treatment groups.
• Correlate neurological deficit scores with histological data from Nissl and Golgi-Cox staining.
• Assess changes in synaptic plasticity-related molecules such as BDNF, GAP-43, PSD-95, and synaptophysin across experimental conditions.
• Compare the neuroprotective outcomes of GABAAR α1-selective PAM CL218872 versus α5-selective NAM MRK-016 treatments.

Strengths

• Data originates from a controlled in vivo mouse model study with defined experimental groups.
• Includes multiple measurement types: behavioral scores, histological analysis, and molecular quantification.
• Shared under a permissive CC BY 4.0 license, facilitating reuse.

Limitations

• Dataset is very small at 12.9 KB, indicating limited scope and likely a summary or subset of the full experimental results.
• No column names or sample data are provided, making the exact structure and variables unclear.
• The experimental focus is on a specific mouse model, limiting direct applicability to other species or conditions.

Provenance

Source

Tingting Chen via figshare.

Collection Method

Data collected from in vivo experiments using a collagenase IV-induced intracerebral hemorrhage mouse model.

Freshness

Last updated March 2026.