Trichinella Vaccine Study Raw Data for Figures

Raw data of Figs 1–9 from a study on Trichinella spiralis serine proteinase (TsSPc) vaccine efficacy in a mouse model. The dataset includes immunological and parasitological measurements supporting the reported 65.7% reduction in enteral adult worm burden and 58.10% reduction in muscle larval burden. It was authored by Jin Yi Wu and shared under a CC BY 4.0 license.

Use Cases

• Analyze the correlation between serum-specific IgG antibody titer levels and reductions in enteral adult burden or muscle larval burden.
• Model the relationship between goblet cell numbers and expression levels of mucins (Muc2, Muc5ac) or pro-inflammatory cytokines (IL-6, TNF-α).
• Compare secretion levels of IFN-γ and IL-4 from spleen, mesenteric lymph node, and Peyer’s patch cells between immunized and control groups.
• Assess the ADCC assay results quantifying antibody-mediated cytotoxicity killing of newborn larvae by peritoneal macrophages.

Strengths

• Data directly supports key published findings, including a 65.7% reduction in enteral adult worm burden and a 58.10% reduction in muscle larval burden.
• Covers multiple experimental endpoints: immunological assays (ELISA, ADCC), parasitological counts, and histopathological measurements (goblet cell numbers).
• Shared under a permissive CC BY 4.0 license, facilitating reuse and analysis.

Limitations

• The dataset is very small at 56.3 KB, indicating limited scope and likely insufficient for standalone machine learning model training.
• Sample data and column structure are unavailable, complicating initial data exploration and requiring manual inspection of the XLSX file.
• Data is specific to a single mouse model study, limiting generalizability to other hosts or Trichinella species.

Provenance

Source

figshare, authored by Jin Yi Wu.

Collection Method

Experimental data generated from a mouse model study evaluating a recombinant TsSPc vaccine.

Freshness

Last updated on 2026-03-24.