Mouse SARS-CoV-2 Infection Data on Hyaluronan and Anti-CD44 Treatment

Raw data from a study investigating the role of hyaluronan (HA) and its receptor CD44 in COVID-19 pathology using a mouse-adapted SARS-CoV-2 strain. The dataset likely contains measurements from bronchoalveolar lavage fluid cytokine/chemokine analysis, flow cytometry of immune cells, and immunofluorescence results. It was authored by Duncan J. Hart and last updated on 2026-05-21.

Use Cases

• Analyze the effect of anti-CD44 monoclonal antibody treatment on survival and weight loss in infected mice based on the described experimental outcomes.
• Investigate changes in cytokine and chemokine profiles in bronchoalveolar lavage fluid following treatment based on the description.
• Study the reduction of neutrophil infiltration in infected lungs using flow cytometry data mentioned in the description.
• Examine the colocalization of HA and immune cell marker CD45 in lung tissue sections via immunofluorescence data described.

Strengths

• Data is associated with a specific, hypothesis-driven study on a relevant COVID-19 pathology mechanism.
• The dataset includes multiple experimental modalities: survival/clinical scoring, cytokine analysis, flow cytometry, and immunofluorescence.
• It is shared under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• The dataset is small at 72.5 KB, indicating a limited experimental scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.

Provenance

Source

figshare

Collection Method

Experimental data from a controlled mouse infection study with SARS-CoV-2 and subsequent anti-CD44 antibody treatment.

Freshness

Last updated 2026-05-21 07:56:22; freshness should be verified.