Rat Liver Lipid Metabolism Data from Folic Acid Intervention Study

102.9 KB of raw data from a rat model study investigating intrauterine growth retardation (IUGR). Laiyi Zhou published this dataset on figshare in 2026, examining the effects of a low-protein diet and postnatal folic acid supplementation on serum triglycerides, free fatty acids, and liver gene expression. Results show IUGR rats had elevated lipid levels and altered liver structure, which were ameliorated by folic acid.

Use Cases

• Modeling the relationship between early-life nutrition and adult metabolic health based on serum triglyceride and free fatty acid levels.
• Analyzing gene expression patterns for lipid metabolism markers like PPARα, Acox1, Acox3, and CPT1.
• Studying pathological liver changes based on histological observations described in the methods.
• Evaluating the therapeutic potential of postnatal folic acid supplementation based on the reported reversal of metabolic dysfunctions.

Strengths

• Data is derived from a controlled experimental model with defined dietary interventions (10% low protein vs. 21% normal protein).
• Includes multiple measurement types: serum ELISA for TG and FFA, liver histology (HE staining), and gene/protein expression analysis (RT-qPCR and WB).
• Licensed under CC-BY-4.0 for open reuse.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The 102.9 KB file size suggests a limited scope, likely containing summary or processed results rather than raw instrument outputs.
• Data reflects a specific rat model study; applicability to human biology may be limited.

Provenance

Source

Laiyi Zhou via figshare.

Collection Method

Experimental data from a rat IUGR model induced by maternal low-protein diet, with subsequent dietary interventions and biochemical/histological/molecular analysis.

Time Range

Covers rat development from birth to 90 days of age.

Freshness

Last updated 2026-04-08 17:32:34.

Geography

Laboratory study; geographic location is not specified.