Chestnut Wood Extract Phytochemical and Bioactivity Data for IBD Research

Dylan Lambert's dataset contains phytochemical and bioactivity data for chestnut wood extract (CWE) related to inflammatory bowel disease (IBD) research. The data, last updated in 2026, includes profiling of 23 phenolic constituents and measurements of anti-inflammatory and antioxidant effects. The dataset is small at 17.7 KB and is available in XLSX format under a CC-BY-4.0 license.

Use Cases

• Identify key phenolic compounds in chestnut wood extract based on the phytochemical profiling of 23 constituents.
• Analyze anti-inflammatory effects based on NF-κB activation and cytokine (IL-6, IL-1β, TNF-α) reduction data.
• Evaluate antioxidant capacity based on intracellular ROS reduction and antioxidant enzyme (SOD-1, GPX-1, catalase) upregulation.
• Investigate epithelial barrier protection mechanisms based on Claudin-1 expression data under inflammatory challenge.
• Study PPARγ modulation pathways based on expression data and synergy with rosiglitazone.

Strengths

• Phytochemical profiling identifies 23 distinct phenolic constituents.
• Functional data includes multiple bioactivity endpoints: cytokine levels, ROS, enzyme expression, and mitochondrial membrane potential.
• Includes in vivo validation data from a Caenorhabd elegans infection model.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 17.7 KB, indicating limited scope.

Provenance

Source

Dylan Lambert via figshare

Collection Method

Data likely generated from laboratory experiments characterizing chestnut wood extract.

Freshness

Last updated 2026-04-29 17:36:26; freshness should be verified.