Rosiglitazone and Ibuprofen Solubility Enhancement Data

Raw data from a study quantifying the mutual solubility enhancement of co-dissolved rosiglitazone and ibuprofen. The dataset includes solubility measurements via HPLC, fluorescence and FT-IR spectroscopy results, and molecular dynamics simulation insights from 30–60 °C. Yaxiang Gong authored the dataset, which was last updated on 2026-03-18.

Use Cases

• Modeling drug-drug solubility interactions based on measured solubility values for rosiglitazone and ibuprofen.
• Analyzing molecular association patterns based on fluorescence intensity and FT-IR spectroscopy data.
• Validating molecular dynamics simulations of solvent-solute compatibility and hetero-association.
• Developing formulation-free strategies for drug dissolution improvement based on the observed mutual solubilization effect.

Strengths

• Includes specific solubility measurements (e.g., rosiglitazone solubility rose from 60.4–79.9 to 69.2–92.4 μg/mL).
• Data is supported by multiple analytical methods: HPLC, fluorescence spectroscopy, FT-IR, and molecular dynamics simulations.
• Released under a permissive CC-BY-4.0 license, allowing for broad reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (271.4 KB), indicating a limited experimental scope.

Provenance

Source

Yaxiang Gong via figshare

Collection Method

Solubility measured by HPLC; fluorescence and FT-IR spectroscopy used; classical molecular dynamics simulations performed.

Freshness

Last updated 2026-03-18 17:30:19; freshness should be verified.