Raw ERG Data and R-Code for Photoreceptor-Specific Splicing Study

A study by Bohye Jeong investigates the role of Musashi protein paralogs MSI1 and MSI2 in photoreceptor-specific alternative splicing. The dataset includes raw ERG data and R-code supporting the analysis of splicing in Cc2d2a, Cep290, Prom1, and Ttc8 genes across combined Msi1 and Msi2 knockout models. The data was last updated on May 14, 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Analyze photoreceptor function based on raw ERG data from knockout models
• Study allele-specific effects on alternative splicing based on the progressive reduction of Musashi alleles
• Reproduce statistical analyses of exon inclusion levels in photoreceptor-specific genes using the provided R-code
• Investigate the relationship between Musashi protein expression levels and splicing regulation

Strengths

• Includes raw ERG data, which is a direct physiological measurement of photoreceptor function
• Provides R-code for analysis, supporting reproducibility
• Data is shared under a permissive CC-BY-4.0 license
• Focuses on four specific photoreceptor-related genes (Cc2d2a, Cep290, Prom1, Ttc8)

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The 3.6 MB size suggests a small dataset, potentially limiting statistical power for some analyses

Provenance

Source

Bohye Jeong

Collection Method

Generated from combined Msi1 and Msi2 knockout experiments in photoreceptor cells.

Freshness

Last updated 2026-05-14 17:44:34; freshness should be verified