Rat Myocardial Metabolomics Data for Epilepsy-Related Cardiac Dysfunction

Metabolomic profiles from myocardial tissues of pentylenetetrazol-induced epileptic rats and control rats, collected for a study on sudden unexpected death in epilepsy (SUDEP). The dataset contains 127 identified differential metabolites and was authored by Yue Hu, last updated on 2026-05-21. Analysis was performed using UHPLC-OE-MS-based non-targeted metabolomics and multivariate statistical methods.

Use Cases

• Identify potential metabolic biomarkers for epilepsy-related cardiac dysfunction based on the 127 differential metabolites.
• Explore biological pathways like amino acid and glycerophospholipid metabolism implicated in epileptic myocardium.
• Validate diagnostic performance of key metabolites using ROC analysis results mentioned in the description.
• Investigate mechanisms of glutamate/GABA imbalance and oxidative stress through altered amino acid levels like L-glutamine and β-alanine.

Strengths

• Contains 127 identified differential metabolites between epileptic and control rat myocardial tissues.
• Metabolomic analysis was performed using UHPLC-OE-MS, a high-resolution mass spectrometry technique.
• Key metabolites demonstrated high diagnostic performance with AUC > 0.98 in ROC analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 7.6 MB, potentially limiting the scope of analysis.

Provenance

Source

figshare, author Yue Hu

Collection Method

UHPLC-OE-MS-based non-targeted metabolomics on myocardial tissues from a pentylenetetrazol (PTZ)-induced epileptic rat model.

Freshness

Last updated 2026-05-21 17:26:19; freshness should be verified.