USP39 Regulation of RIG-I and STING Antiviral Signaling Pathways

Jiazheng Quan uploaded raw numerical data supporting a study on ubiquitin-specific peptidase 39 (USP39). The data, shared on figshare under a CC-BY-4.0 license, likely contains experimental results quantifying the role of USP39 in regulating RIG-I and cGAS-STING signaling pathways against viral infections. The dataset was last updated on May 11, 2026.

Use Cases

• Analyze the relationship between USP39 expression and type I interferon levels based on the described antiviral immune response.
• Model the impact of USP39 on viral replication rates for RNA (e.g., VSV, H1N1 PR8) and DNA (e.g., HSV-1) viruses.
• Investigate protein-protein interactions and stabilization mechanisms based on the described USP39-STING interaction and deubiquitination activity.
• Study post-transcriptional control of gene expression based on the described role of USP39 in promoting pre-RIG-I mRNA splicing.

Strengths

• Data is directly tied to a specific mechanistic study on USP39, RIG-I, and STING.
• The dataset is openly available under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (74.1 KB), indicating limited scope.

Provenance

Source

Jiazheng Quan

Collection Method

Likely contains experimental results from in vitro and in vivo studies described in the associated research.

Freshness

Last updated 2026-05-11 17:47:32; freshness should be verified.