Proteomics Results for Breast Cancer Stage IIIA from Plasma Extracellular Vesicles

Proteomic profiles from plasma small extracellular vesicles of 76 obese, chemotherapy-naïve breast cancer patients and 36 obese controls. The dataset, shared by Amr Ahmed WalyEldeen on figshare under CC-BY-4.0, identifies Fibronectin 1 and von Willebrand Factor as candidate markers associated with diagnosis and therapy response. Last updated on May 5, 2026, the 6.6 MB XLSX file contains results from nanoLC-MS/MS analysis.

Use Cases

• Identify diagnostic protein biomarkers for breast cancer based on proteomic signatures from plasma small extracellular vesicles.
• Investigate associations between extracellular vesicle proteins and aggressive cancer subtypes like triple-negative breast cancer.
• Analyze protein interaction networks involving Fibronectin 1, von Willebrand Factor, Syndecan-2, and Galectin-3 for therapeutic target discovery.
• Validate potential markers for therapy response prediction using ROC-Plotter and drug-gene interaction analyses referenced in the description.

Strengths

• Includes data from 112 total subjects (76 patients, 36 controls), providing a basis for comparative analysis.
• Proteomic profiling was performed using high-resolution nanoLC-MS/MS, suggesting detailed molecular data.
• Independent validation via western blot for candidate markers FN1, VWF, and SDC2 is described, indicating methodological rigor.
• Data is shared under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Row count and specific column-level documentation are unknown, which complicates suitability assessment and data interpretation.
• The dataset is relatively small at 6.6 MB, which may limit the scope of complex multivariate analyses.
• Data may reflect bias inherent to the specific cohort of obese breast cancer patients studied.

Provenance

Source

figshare

Collection Method

Plasma small extracellular vesicles were enriched and characterized by transmission electron microscopy, dynamic light scattering, and specific EV markers. Proteomic profiling was performed using nanoLC-MS/MS.

Freshness

Last updated 2026-05-05 17:27:35