Clinical Trial Termination Reasons and Adverse Event Risk, 2009-2017

Samruddhi Suresh Yerunkar's dataset, last updated April 2026, categorizes reasons for clinical trial termination. It includes 2,253 trials from German university medical centers (2009-2017) and 1,091 from Californian centers (2014-2017), with 10% and 14% termination rates respectively. The data supports analysis of termination causes and exploratory risk assessment for serious adverse events in a subset of trials.

Use Cases

• Classifying trial termination reasons based on registry data.
• Comparing trial characteristics between terminated and completed studies.
• Estimating risk for serious adverse events in trials terminated for non-scientific reasons.
• Analyzing results reporting rates across different geographic cohorts.

Strengths

• Includes 3,344 total clinical trials from two distinct geographic cohorts.
• Provides specific termination rates (10% German, 14% Californian) and reasons (e.g., 65-67% non-scientific).
• Contains exploratory analysis results for serious adverse event risk (RR 1.05, 95% CI: 0.76–1.44).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The SAE risk analysis is based on a very limited subset of 14 trials.

Provenance

Source

ClinicalTrials.gov and EU Clinical Trials Register (EUCTR).

Collection Method

Cohorts of trials affiliated with German and Californian university medical centers were investigated.

Time Range

German cohort: 2009-2017; Californian cohort: 2014-2017.

Freshness

Last updated 2026-04-15 17:36:32; freshness should be verified.

Geography

Germany and California, United States.