Representative N. gonorrhoeae Draft Genomes with Opa Allele Analysis

219 complete genomes of Neisseria gonorrhoeae clinical isolates assembled using long-read sequencing. The dataset was created by QinQin Yu to quantitatively assess variation in the opacity-associated (Opa) antigen family, revealing that opa genes are on average 74 times more diverse than the rest of the genome. It was last updated on May 11, 2026.

Use Cases

• Analyzing Opa allele diversity and evolution based on the quantitative assessment of 219 genomes
• Studying antigen variation for vaccine design based on the complete assembly of Opa loci
• Investigating reading frame expression patterns based on the count of in-frame versus out-of-frame opa genes
• Comparing genomic distance and allele similarity based on the correlation analysis described

Strengths

• Contains 219 complete genomes assembled from phylogenetically diverse clinical isolates
• Uses long-read sequencing to resolve multiple copies of opa genes, overcoming a limitation of short-read methods
• Quantitative analysis reveals opa genes are 74 times more diverse than the rest of the genome

Limitations

• Dataset size is 47.7 KB, indicating a very limited scope of data
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Long-read sequencing and assembly of clinical isolates, with bioinformatics and phylogenetics tools developed for analysis.

Freshness

Last updated 2026-05-11 17:47:03