LHON Vision Acuity Trajectories for 27 Patients Over 10 Years

27 genetically confirmed Leber hereditary optic neuropathy (LHON) patients (53 eyes) from a Japanese tertiary eye hospital were followed for at least 10 years. Best-corrected visual acuity (BCVA) data in logMAR was collected from onset to 120 months and modeled across Acute, Chronic, and Late Chronic phases. The dataset, created by Yasuyuki Takai and shared under CC-BY-4.0, provides descriptive benchmarks for long-term visual outcomes in this mitochondrial disorder.

Use Cases

• Modeling long-term visual acuity trajectories based on piecewise linear phases described in the study
• Estimating cumulative probabilities of achieving specific BCVA thresholds (e.g., ≤1.6 logMAR) using Kaplan–Meier analysis
• Comparing visual outcome trends between different genetic subgroups, such as the m.11778G>A variant mentioned

Strengths

• Longitudinal data spanning a minimum of 10 years of continuous follow-up per patient
• Focus on a specific, genetically confirmed patient cohort (LHON) from a single tertiary center
• Analysis includes patient- and eye-level random effects in statistical models

Limitations

• Modest sample size of 27 patients with long-term follow-up, which may limit generalizability
• Row count and column-level documentation are unknown, requiring inspection after download
• Data reflects a specific Japanese cohort, and results may not be directly generalizable to other populations

Provenance

Source

Single-center retrospective cohort study at a tertiary eye hospital in Japan

Collection Method

Retrospective data collection from genetically confirmed LHON patients with ≥10 years of follow-up

Time Range

From disease onset to 120 months (10 years) per patient

Freshness

Last updated 2026-04-28 17:27:15

Geography

Japan