Response Surface Factor Design for Cefotaxime Sodium Synthesis Optimization

Experimental data from a Box-Behnken response surface methodology study optimizing the synthesis of cefotaxime sodium (CTX). The dataset includes results for yield, impurity content, and green chemistry metrics under varying process conditions. It was authored by Wang Yizhang and shared on figshare under a CC-BY-4.0 license.

Use Cases

• Modeling the relationship between reaction temperature, eluent dosage, and salt-forming agent ratio on product yield.
• Analyzing trade-offs between product yield and impurity content based on HPLC analysis results.
• Evaluating the environmental performance of chemical synthesis processes using green chemistry evaluation scores.
• Validating process optimization models for pharmaceutical manufacturing.

Strengths

• Specific optimal process conditions are reported: reaction temperature 14.8°C, eluent dosage 104.4 mL, and salt-forming agent ratio 1:1.
• Quantitative results are provided, including a yield of 93.66%, total impurity content of 3.93%, and a green chemistry evaluation score of 94.44.
• Multiple analytical validation methods are described: HPLC, XRD, and SEM.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 5.5 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Experimental data from a Box-Behnken response surface methodology study.

Freshness

Last updated 2026-05-14 17:29:28; freshness should be verified.