Heterogeneity Test Results for Glomerulonephritis eQTL Analysis

1.6 MB of Excel data containing results from a multi-omics Mendelian randomization analysis of glomerulonephritis subtypes. The dataset, authored by Guoqiang Li and last updated in April 2026, includes proteomic and transcriptomic quantitative trait loci (pQTL/eQTL) applied to GWAS for acute, chronic, IgA nephropathy, and membranous nephropathy. Bayesian colocalization, replication in the FinnGen cohort, and translational annotations were used to identify potential therapeutic targets.

Use Cases

• Validate causal gene targets for glomerulonephritis subtypes based on Mendelian randomization results.
• Prioritize drug repurposing candidates based on translational annotations linking genes like IL6R and MBL2 to immune pathways.
• Compare genetic architecture across GN subtypes using the identified candidate genes (e.g., RECQL for acute GN, HCK for membranous nephropathy).
• Assess the strength of causal inference using the Bayesian colocalization results (PPH4 > 0.8) for genes like HCK and CD302.

Strengths

• Includes results from systematic multi-omics analysis integrating proteomic and transcriptomic QTLs.
• Provides replication and meta-analysis using the independent FinnGen cohort.
• Contains downstream translational annotations evaluating mouse knockout phenotypes and drug repositioning.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect methodological bias inherent to the specific Mendelian randomization and colocalization approaches used.

Provenance

Source

figshare

Collection Method

Results from a systematic multi-omics Mendelian randomization analysis.

Freshness

Last updated 2026-04-16 17:46:19; freshness should be verified.