Heterogeneity Test Results for Glomerulonephritis Multi-Omics Mendelian Randomization

558.2 KB of proteomic and transcriptomic quantitative trait loci results from a Mendelian randomization analysis of glomerulonephritis subtypes. The dataset, created by Guoqiang Li and last updated April 16, 2026, likely contains statistical evidence for causal genes like HCK and IL6R. Bayesian colocalization and replication in the FinnGen cohort were used to strengthen causal inference.

Use Cases

• Validate causal gene candidates for glomerulonephritis subtypes based on proteomic-wide Mendelian randomization results
• Prioritize therapeutic targets for drug repositioning based on translational annotations for immune and complement pathways
• Compare genetic architecture across GN subtypes using transcriptomic-wide MR results for genes like RECQL and TIMP4
• Strengthen causal inference for specific loci using Bayesian colocalization analysis results with high posterior probability
• Perform meta-analysis across datasets using replication results from the independent FinnGen cohort

Strengths

• Results are supported by Bayesian colocalization analysis with strong posterior probability (PPH4 > 0.8) for several genes.
• Independent replication and meta-analysis were conducted using the FinnGen cohort, providing additional consistency.
• The dataset integrates proteomic and transcriptomic quantitative trait loci from established resources.
• Downstream translational annotations highlight potential hub targets within immune and complement-related pathways.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset's 558.2 KB size suggests a limited scope, likely containing summary results rather than raw data.
• Description metadata is limited; actual data structure and field semantics must be inferred after download.

Provenance

Source

figshare

Collection Method

Systematic multi-omics Mendelian randomization analysis applying established pQTL/eQTL resources to GWAS of GN subtypes.

Freshness

Last updated 2026-04-16 17:46:17