Pleiotropy Test Results for Glomerulonephritis Genetic Studies

Results from a systematic multi-omics Mendelian randomization analysis linking proteomic and transcriptomic quantitative trait loci to genome-wide association studies of four glomerulonephritis subtypes. The dataset was authored by Guoqiang Li and last updated on April 16, 2026. It likely contains statistical results from Bayesian colocalization, replication, and meta-analysis.

Use Cases

• Validate causal gene targets for glomerulonephritis subtypes based on eQTL/pQTL associations
• Prioritize drug repurposing candidates based on identified hub targets like IL6R and MBL2
• Compare genetic architecture across GN subtypes using the identified candidate genes
• Strengthen causal inference for specific genes using the Bayesian colocalization results

Strengths

• Dataset is licensed under CC-BY-4.0, allowing for open reuse and redistribution.
• Analysis includes independent replication and meta-analysis using the FinnGen cohort.
• Translational annotations highlight potential hub targets within immune and complement pathways.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 938.2 KB file size suggests a limited scope of results.

Provenance

Source

figshare

Collection Method

Results from a systematic multi-omics Mendelian randomization analysis applying pQTL/eQTL resources to GWAS.

Freshness

Last updated 2026-04-16 17:46:21; freshness should be verified.