Pleiotropy Test Results for Glomerulonephritis Genetic Targets

Results from a systematic multi-omics Mendelian randomization analysis of four glomerulonephritis subtypes. The dataset includes proteomic and transcriptomic quantitative trait loci applied to GWAS data, with replication in the FinnGen cohort. It was authored by Guoqiang Li and last updated on April 16, 2026.

Use Cases

• Validate causal genetic targets for glomerulonephritis subtypes based on pQTL/eQTL MR analysis.
• Prioritize therapeutic candidates for drug repositioning based on colocalization and mouse knockout evidence.
• Compare genetic architecture across GN subtypes using identified risk and protective genes.
• Integrate findings with immune and complement pathway annotations to identify hub targets.

Strengths

• Includes replication and meta-analysis using the independent FinnGen cohort.
• Integrates multiple evidence layers: Bayesian colocalization, mouse knockout phenotypes, and computational pharmacology.
• Focuses on four specific GN subtypes: acute, chronic, IgA nephropathy, and membranous nephropathy.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific GWAS and proteomic/transcriptomic resources used.

Provenance

Source

figshare

Collection Method

Systematic multi-omics Mendelian randomization analysis using established pQTL/eQTL resources and GWAS.

Freshness

Last updated 2026-04-16 17:46:18; freshness should be verified.