Transcriptomic-wide Mendelian Randomization Results for Glomerulonephritis

A multi-omics Mendelian randomization analysis dataset linking proteomic and transcriptomic quantitative trait loci to genome-wide association studies for four glomerulonephritis subtypes. The dataset includes results from Bayesian colocalization, replication in the FinnGen cohort, and translational annotations for potential therapeutic targets. Author Guoqiang Li published the 161.8 KB Excel file on figshare in April 2026.

Use Cases

• Validate causal gene candidates for glomerulonephritis subtypes based on Mendelian randomization results
• Prioritize drug repurposing targets based on translational annotations for immune and complement pathways
• Compare genetic architecture across GN subtypes using identified risk and protective factors
• Assess colocalization evidence for shared causal variants between pQTL/eQTL and GWAS signals

Strengths

• Results are supported by Bayesian colocalization analysis with strong posterior probabilities (PPH4 > 0.8)
• Independent replication and meta-analysis were conducted using the FinnGen cohort
• Downstream translational annotations highlight specific hub targets like IL6R and MBL2

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is small (161.8 KB), indicating limited scope

Provenance

Source

figshare

Collection Method

Systematic multi-omics Mendelian randomization analysis applying pQTL/eQTL resources to GWAS data

Freshness

Last updated 2026-04-16 17:46:15