Cefotaxime Sodium Synthesis Process Optimization via Response Surface Method

5.5 KB of experimental results from a Box-Behnken response surface design optimizing the synthesis of cefotaxime sodium (CTX). The dataset, authored by Wang Yizhang and last updated in May 2026, contains the model and results used to determine optimal reaction conditions for yield, quality, and environmental performance.

Use Cases

• Optimizing chemical reaction parameters based on yield and impurity data.
• Training models for process optimization in pharmaceutical manufacturing based on experimental design results.
• Evaluating the environmental performance of chemical processes using green chemistry metrics.

Strengths

• Specific optimal conditions are provided: reaction temperature 14.8°C, eluent dosage 104.4 mL, and a 1:1 salt-forming agent ratio.
• The optimized process achieved a yield of 93.66% and a green chemistry evaluation score of 94.44, as stated in the description.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 5.5 KB, indicating limited scope.

Provenance

Source

Wang Yizhang via figshare

Collection Method

Data was generated through laboratory experiments using single-factor tests and a Box-Behnken response surface design.

Freshness

Last updated 2026-05-14 17:29:29; freshness should be verified.