Risk Gene Loci: 11 Genome-Wide Significant Loci for Age-Related Eye Disease

A genetic study identifies statistically prioritized candidate SNPs associated with Age-related eye disease (ARED) variants. Luqi Gao created this dataset using Genomic Structural Equation Modeling and post-processing analysis of GWAS, last updated in May 2026. The research presents a genetic landscape of ARED by analyzing tissue-, cell layer-, and genomic element-associated gene signals.

Use Cases

• Prioritize candidate genes for functional validation based on identified statistically prioritized SNPs.
• Investigate tissue-specific gene expression signals in relation to age-related ocular vulnerabilities.
• Conduct pathway enrichment analyses using the 11 genome-wide significant loci.
• Validate genetic findings from GWAS on unmeasured phenotypes using Genomic-SEM methodology.

Strengths

• Identifies 11 genome-wide significant loci, providing specific genetic targets.
• Applies multiple transcriptome-wide association approaches for functional annotation.
• Released under a permissive CC-BY-4.0 license, allowing for wide reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (10.7 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Genomic Structural Equation Modeling (Genomic-SEM) and Post-processing analysis of Genome-Wide Association Studies (GWAS).

Freshness

Last updated 2026-05-14 17:48:44; freshness should be verified.